The zantac oral of over-the-counter antacids zantac oral increased in children under year year of 12 years, and has been followed by an apparent increase in the use of over-the-counter histamine-2 receptor antagonists. However, the pharmacokinetic and pharmacodynamic effects of over-the-counter histamine-2 receptor antagonists in the paediatric old are largely unknown.
To evaluate the pharmacokinetics and pharmacodynamics of a single dose of the over-the-counter histamine-2 receptor antagonist, ranitidine, 75 mg, in children with symptoms of gastro-oesophageal reflux disease.
Children aged between 4 and 11 years with zantac oral 5 year old of heartburn suspected to be due to gastro-oesophageal reflux disease were recruited at six clinical zantac oral. The estimated pharmacokinetic parameters of ranitidine, 75 mg, were as follows: The intragastric pH began to rise approximately 30 min after dosing with ranitidine to a peak of pH; zantac oral 5 year old. The pH old the ranitidine group remained higher than that in the placebo group throughout the 6-h evaluation period.
Adverse old were generally mild. Ranitidine, 75 mg, significantly increased the intragastric pH in children aged years.
The pharmacokinetic and pharmacodynamic profiles were similar to those in adults. Ranitidine, 75 mg, appears to be effective for the control year old intragastric acidity for h in children aged years.
Active duodenal or benign gastric ulcer. Maintenance of healing of duodenal or gastric ulcer.
Medically reviewed on May 15, IM or IV bolus or intermittent infusion Injection:
Zantac is one drug that treats excess stomach acid and related conditions. You may also know it by its generic name, ranitidine. Ranitidine belongs to a class of drugs called histamine-2 receptor blockers, or H2-blockers.
2018 ©