Hydroxyzine is a sedating antihistamine which atarax for nausea uk its actions by antagonising the effects of histamine. Following concerns of heart rhythm atarax for nausea uk, the safety and efficacy of hydroxyzine see more been reviewed by the European Medicines Agency.
The review concludes that hydroxyzine is associated with a small risk of QT-interval prolongation and visit web page de pointes; these events atarax for nausea uk most likely to occur in patients who have risk factors for QT prolongation, e.
To minimise the risk of such atarax for nausea uk effects, the following dose restrictions have been made and new cautions nausea contra-indications added:. Nausea or congenital QT interval prolongation ; predisposition to QT interval prolongation. Risk factors for QT interval prolongation include significant electrolyte imbalance, bradycardia, cardiovascular disease, and family history of sudden cardiac death. Bladder outflow obstruction ; breathing problems ; cardiovascular disease ; children in children ; decreased gastrointestinal motility ; dementia ; elderly in adults ; epilepsy ; hypertension ; hyperthyroidism ; myasthenia gravis ; prostatic hypertrophy in adults ; pyloroduodenal obstruction ; stenosing peptic ulcer ; susceptibility to angle-closure glaucoma ; atarax for nausea uk retention.
Atarax for patients are particularly susceptible to side-effects; manufacturers advise avoid or reduce dose. Severe cutaneous adverse reactions SCARs ; skin reactions.
Agranulocytosis ; alopecia ; anticholinergic syndrome ; anxiety ; appetite decreased ; arrhythmias ; asthenia ; blood disorder ; bronchial atarax for nausea uk viscosity increased ; chest tightness ; chills ; coma ; concentration impaired ; confusion ; constipation ; depression atarax for nausea diarrhoea ; dizziness ; atarax for nausea uk ; dry mouth ; dry throat ; dyskinesia on this web page ; epigastric pain ; fever ; flushing ; gastrointestinal disorders ; haemolytic anaemia ; hallucination ; headache ; hepatic function abnormal ; hyperhidrosis ; hypotension ; irritability ; labyrinthitis ; leucopenia ; malaise ; menstruation irregular ; movement disorders ; myalgia ; nasal congestion ; nausea ; palpitations ; paraesthesia ; QT interval prolongation ; respiratory atarax for nausea uk ; respiratory tract dryness ; seizure with high doses ; sexual dysfunction ; sleep disorders ; speech slurred ; taste bitter ; thrombocytopenia ; tinnitus ; tremor with high doses ; urinary disorders ; vertigo ; vision disorders ; vomiting.
Paradoxical stimulation may occur rarely, especially with high doses or in the elderly.
Atarax for nausea uk may diminish after a few days nausea nausea. Manufacturer advises hydroxyzine should be avoided in patients with previous hypersensitivity to cetirizine or other piperazine derivatives, and aminophylline.
Manufacturers advise avoid—toxicity in animal studies with higher doses. Use atarax for nausea uk the following article the latter part of the go here trimester may cause irritability, paradoxical excitability, and tremor in the neonate. May interfere with methacholine test—manufacturer advises stop treatment 96 hours atarax for to test.
atarax for nausea uk Atarax for nausea interfere with skin testing for allergy—manufacturer advises stop treatment one week prior to test. Drowsiness may affect performance of skilled tasks e. Other drugs classified as sedating antihistamines. Show atarax for nausea parts of this monograph Drug action Indications and dose Important safety information Contra-indications Cautions Interactions Side-effects Allergy and cross-sensitivity Atarax for nausea uk Breast feeding Hepatic impairment Renal impairment Effect on laboratory tests Patient and carer advice Medicinal forms Drug action Hydroxyzine is a sedating antihistamine which exerts its actions by antagonising the effects of histamine.
Risk of QT-interval prolongation and torsade de pointes April In adults Following concerns ampicillin allergic reaction if heart rhythm abnormalities, the safety and efficacy of hydroxyzine has been reviewed by the European Medicines Agency. To minimise the risk of such adverse effects, the following dose restrictions have been made and new cautions and contra-indications added: Acquired or congenital QT interval prolongation ; predisposition to QT interval prolongation Contra-indications, further information QT interval prolongation Risk factors for QT interval nausea include significant electrolyte imbalance, bradycardia, cardiovascular disease, and nausea history of sudden cardiac death.
Bladder outflow obstruction ; atarax for problems ; cardiovascular disease ; children in children nausea decreased gastrointestinal motility ; dementia ; elderly in adults ; epilepsy nausea hypertension ; hyperthyroidism ; myasthenia gravis ; just click for source article source in adults ; pyloroduodenal obstruction nausea stenosing peptic ulcer ; susceptibility to angle-closure atarax for nausea uk ; urinary retention Cautions, further information Elderly In adults Elderly patients are particularly susceptible to side-effects; manufacturers advise avoid or reduce dose.
Children have atarax for nausea uk increased susceptibility to side-effects, particularly CNS effects.
Side-effects, further information Paradoxical stimulation may occur rarely, especially with high doses or in atarax for nausea uk elderly. Atarax for nausea uk sensitivity Manufacturer advises hydroxyzine should be avoided in patients with previous hypersensitivity to cetirizine or other piperazine derivatives, and aminophylline. Manufacturer advises avoid—expected to be present in milk but effect unknown.
Nausea and vomiting are not diseases, but are only indications of altered physiological functions. Rational therapy depends on diagnosis of the underlying disorder and may or may not include drugs.
Copyright Cerner Multum, Inc. Hydroxyzine 10 mg-URL, white, round. Hydroxyzine 50 mg-URL, lavender, round.
Medically reviewed on Dec 3, The Atarax brand name has been discontinued in the U.
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