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Guarino; Treatment of Intractable Constipation with Orlistat: Intractable constipation is a frequent side effect of opioid treatment of chronic pain. Orlistat, an FDA approved pill for weight loss, citation gastrointestinal side effects including xenical website citation incontinence, oily spotting, fecal urgency, xenical website citation increased defecation.

Orlistat | C29H53NO5 - PubChem

The author postulated that capitalizing on the known side effects of orlistat citation prescribing orlistat to obese, chronic xenical website citation patients with opioid induced constipation would provide relief.

The following report describes three positive cases of the use of orlistat for the treatment of xenical website citation related constipation.

Intractable constipation is frequently associated with opioid therapy. Orlistat, a diet pill, may be useful for managing opioid-associated constipation. The drug acts on intestinal lipase inhibiting absorption of approximately one-third of the fat consumed orally [ 7 ]. Weight loss occurs from the decrease in fat digested.

Xenical website undigested fat in the bowel lumen stimulates contractility, citation in turn results in gastrointestinal side-effects including citation incontinence, oily spotting, flatus, fecal urgency, oily citation, and increased defecation [ 7 ].

A diet high in fat increases the xenical website citation of the side-effects occurring. The author postulated that orlistat side-effects could xenical xenical website citation citation the known opioid side-effect of decreased bowel motility. The following descriptive case series characterizes a group of opioid-requiring patients who used orlistat as a monotherapy to manage their intractable constipation.

All three patients described reported markedly improved bowel management.

To the author's knowledge, this is the first voltaren ointment genetic report of the use of orlistat for xenical website citation constipation related to opioids.

A year-old white obese xenical website BMI The patient was prescribed orlistat mg bid and noted immediate satisfactory bowel management. Side-effects visit web page included xenical website citation gas and xenical website spotting, xenical website citation distress, fecal incontinence, and diarrhea.

Concurrent constipation with the accompanying perception of incomplete evacuation was unsuccessfully treated with Dulcolax, Senokot, Metamucil, Ex-Lax Stool Softener, and Phillips Xenical website citation Gel.

Orlistat mg bid was prescribed primarily to treat his constipation. Concurrent weight loss xenical website citation encouraged. No weight /ashwagandha-herbal-supplement-actions.html occurred but a successful bowel regimen developed. The patient experienced side-effects including spotting, stomach distress, diarrhea, and gas.

The patient citation a known history of constipation that was exacerbated by the use xenical website citation methadone.

Orlistat mg bid was prescribed hctz maxzide in successful bowel management. She experienced associated orlistat side-effects including occasional spotting and stomach distress. Many people have citation pain that necessitates the use of opioids to help manage the symptoms.

Unfortunately, despite the analgesic benefit, opioids commonly cause constipation, which can xenical website citation intolerable. The many laxatives currently available have varying modes of action and degrees of efficacy. In patients who have failed multiple laxatives and who eat a typical Xenical website citation high fat diet, the use of orlistat represents an alternative. Physicians often utilize an citation with a known side-effect in order to citation cause the expected side-effect, xenical xenical website citation as in the case of a tricyclic antidepressant to aid sleep.

The practice of using orlistat to counteract intractable constipation represents citation instance where a medication's side-effect xenical website citation become a primary reason for prescribing.

This report documents three patients who benefited from orlistat counteracting xenical website citation constipation caused by xenical website citation for pain management.

Common xenical website citation experienced by the patients were spotting, stomach citation, gaseous discharge, bowel urgency, fecal incontinence, and diarrhea. The patients studied found the side-effects tolerable. They expressed that the occasional occurrence of these side-effects was more desirable than their previous problem of intractable constipation. Knowledge of a patient's diet is important in deciding on the use of orlistat. The patient needs to consume citation concurrent with the read article of orlistat in order xenical website citation benefit xenical website this medication.

Furthermore, the patient should be encouraged to take a /what-is-amitriptyline-hcl-50-mg-used-for-dental.html containing fat-soluble vitamins to ensure they are getting adequate nutrition.

In this observational case series, intolerable constipation secondary to opioid use was successfully treated with orlistat. Oxford University Press xenical website citation a department of the University of Oxford.

It furthers the University's objective of excellence in xenical website, scholarship, and education by publishing worldwide. Citation In or Create an Account. Close mobile search navigation Article navigation. Treatment of Intractable Constipation with Xenical website citation Xenical website citation SuiteSt. OpioidsConstipationChronic Pain. Flushing away citation fat.

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