Vytorin pi image

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Medically reviewed on Feb 1, Therapy with lipid-altering agents should be only one component of vytorin pi image risk factor intervention see more individuals at significantly increased risk for atherosclerotic vascular disease due to hypercholesterolemia. Drug therapy is indicated vytorin pi image an adjunct dilantin seizure medicine 10 mg diet when the response to a diet restricted in vytorin image fat and cholesterol and other nonpharmacologic measures alone has been inadequate.

Vytorin is indicated for the reduction of elevated total-C and LDL-C in patients with homozygous familial hypercholesterolemia, as an adjunct to other lipid-lowering treatments e.

No incremental benefit of Vytorin on cardiovascular morbidity and mortality over and above that demonstrated for simvastatin has been established. Vytorin should be taken vytorin pi image a single image dose in image evening, with vytorin pi image without food. After initiation or titration of Vytorin, lipid levels may be analyzed after 2 or more weeks and dosage adjusted, if needed.

Vytorin should be used as an adjunct to other lipid-lowering treatments e. In such patients, higher doses link be used with caution vytorin pi image close monitoring [see Warnings vytorin pi image Precautions 5. No dosage adjustment is necessary in geriatric patients [see Clinical Pharmacology The cause of the increased risk of myopathy is not known.

Vytorin image is also unknown if the risk for myopathy with coadministration of simvastatin with lipid-modifying doses of niacin-containing products observed in Chinese patients image href="/augmentin-675-mg-dosage.html">this web page to image Asian patients.

Simvastatin image causes myopathy manifested as muscle pain, tenderness or weakness vytorin pi image creatine kinase above ten times the upper limit of normal ULN.

vytorin

Myopathy sometimes vytorin the form of rhabdomyolysis vytorin image or without acute renal failure secondary to myoglobinuria, and vytorin pi image fatalities have occurred.

The risk of myopathy is increased by elevated plasma levels of simvastatin and simvastatin acid. The risk of myopathy, including rhabdomyolysis, is dose related.

The incidence of myopathy with 80 mg 0. In these trials, patients were carefully monitored and some vytorin medicinal products were excluded.

In a clinical vytorin image vytorin image which 12, patients with a history of myocardial infarction were treated vytorin image simvastatin mean follow-up 6. The incidence of myopathy, including rhabdomyolysis, was highest during the first year and then notably decreased image the subsequent years of treatment.

In this trial, patients were carefully monitored and some interacting medicinal products were excluded.

Vytorin - FDA prescribing information, side effects and uses

The risk image myopathy, including rhabdomyolysis, is greater in patients on simvastatin 80 mg compared with other statin therapies with similar image greater LDL-C-lowering efficacy and compared with lower doses vytorin pi image simvastatin. Patients should be advised of the increased risk of vytorin, including rhabdomyolysis, and to report promptly any vytorin image muscle pain, tenderness or weakness. If symptoms occur, treatment should be discontinued immediately [see Warnings and Precautions 5.

Vytorin image a median image period of 4.

In postmarketing experience with ezetimibe, cases of myopathy and rhabdomyolysis have been reported. Most patients who developed rhabdomyolysis were vytorin pi image a statin prior to image ezetimibe. However, rhabdomyolysis image been reported with ezetimibe monotherapy and with the addition of ezetimibe vytorin pi image agents known to be associated with increased risk of rhabdomyolysis, such as fibric acid derivatives.

Vytorin and a fenofibrate, if taking concomitantly, vytorin pi image both be immediately discontinued if myopathy is diagnosed or suspected. There have been rare reports of immune-mediated necrotizing myopathy IMNMan autoimmune myopathy, associated with statin use.

IMNM is vytorin pi image by: All patients starting therapy with Vytorin or whose dose of Vytorin is being increased click to see more be advised of the risk of myopathy, including rhabdomyolysis, and told to report promptly any unexplained muscle pain, vytorin pi image or weakness particularly if accompanied by malaise or fever or if muscle signs and symptoms persist after discontinuing Vytorin.

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