Venlafaxine venlafaxine, sold under the brand name Effexor among others, venlafaxine xr to ir an antidepressant of the serotonin-norepinephrine reuptake inhibitor SNRI class.
First introduced by Wyeth innow marketed by Pfizer venlafaxine xr to ir, it is licensed for the treatment of major depressive disorder MDDgeneralized anxiety venlafaxine xr to ir GADpanic disorderand social phobia.
A comparative meta-analysis of 21 major antidepressants found that venlafaxine, agomelatineamitriptylineescitaloprammirtazapineparoxetineand vortioxetine were more effective venlafaxine other antidepressants although venlafaxine quality of many comparisons was assessed as low or very low. The venlafaxine of life-threatening or lethal clindamycin dental dosage 12 year venlafaxine for suicidal overdoses of venlafaxine is lower than for the /global-lithium-production-geological-survey.html bupropion but higher than almost all of the SSRIsand equal to citalopram.
Invenlafaxine was the venlafaxine xr to ir most commonly prescribed antidepressant on the U. Venlafaxine is used primarily for the treatment of depressiongeneral anxiety disordersocial phobiapanic disorderand vasomotor venlafaxine.
Some doctors may prescribe venlafaxine off label for the treatment of diabetic neuropathy in a similar manner to duloxetine and migraine prophylaxis in some people, however, venlafaxine can exacerbate or cause migraines. Studies have shown venlafaxine's effectiveness for these conditions, [16] although agents that are marketed for this purpose like pregabalin or venlafaxine are likely preferred. It has also been found to reduce the severity of 'hot flashes' in menopausal women and men on hormonal therapy for the treatment of prostate cancer.
Due to its action on both the serotoninergic and adrenergic systems, venlafaxine is also used as a treatment to reduce episodes of cataplexya form of muscle weakness, in patients with the sleep disorder narcolepsy. Multiple double blind studies show venlafaxine's effectiveness in treating depression. Venlafaxine venlafaxine similar venlafaxine xr to ir to venlafaxine tricyclic antidepressants amitriptyline Elavil and imipramineand is better tolerated than amitriptyline.
Venlafaxine xr to ir efficacy venlafaxine xr to ir similar to or better than sertraline Zoloft and fluoxetine Venlafaxine xr to irdepending on the criteria and rating scales used. Higher doses of venlafaxine are more effective, and more patients cost acyclovir capsule remission or were "very much improved". The efficacy was similar if the number of patients who achieved "response" or were "improved" was considered.
A meta-analysis comparing venlafaxine and combined groups of SSRI or tricyclic antidepressants venlafaxine venlafaxine's superiority. Similar improvement was observed in both groups.
See also List of this web page effects of venlafaxine. The US Food and Drug Administration body Venlafaxine xr to venlafaxine requires all antidepressants, including venlafaxine, to carry a black box warning with a generic warning about a possible suicide risk. A meta analysis of 21 clinical trials of venlafaxine for here treatment of depression in adults found that venlafaxine to placebo, venlafaxine reduced the risk of suicidal thoughts and behavior.
A study conducted in Finland followed more than 15, patients for 3.
At the same time, fluoxetine Prozac halved the suicide risk. Venlafaxine xr to ir another study, the data on more thancases were obtained from the UK venlafaxine xr to ir practice research database.
At baseline, patients prescribed venlafaxine had a greater number of risk factors for suicide venlafaxine as prior suicide attempts than patients treated continue reading other anti-depressants.
The patients taking venlafaxine had significantly higher risk of completed suicide than the ones on fluoxetine or citalopram Celexa. After adjusting for known risk factors, venlafaxine xr to ir was associated with an increased risk of suicide relative to fluoxetine and dothiepin that was not statistically significant.
A statistically significant greater risk for attempted suicide remained after adjustment, but the authors concluded that it could be due to residual confounding. An venlafaxine xr to ir of clinical trials by the FDA statisticians showed the incidence of suicidal behaviour among the adults on venlafaxine to be not significantly different from fluoxetine or placebo.
Venlafaxine is contraindicated in children, adolescents and young adults.
According to the FDA analysis of clinical trials [28] venlafaxine caused a statistically significant 5-fold increase in suicidal ideation and behaviour in persons younger than In another analysis, venlafaxine was no better than venlafaxine among children 7—11 years oldbut improved depression in adolescents venlafaxine years old.
However, in both groups, hostility and suicidal behaviour increased in comparison to those receiving a venlafaxine. People stopping venlafaxine commonly experience discontinuation symptoms such as dysphoriaheadachesnauseairritabilityemotional labilitysensation of electric shocks, and sleep disturbance. The higher risk and increased severity of discontinuation syndrome symptoms relative to other antidepressants may be related to the short half-life of venlafaxine and its active metabolite.
Effexor and Effexor XR are similar antidepressant compounds. However, Effexor XR is also prescribed for anxiety disorders, as well as depression. Effexor XR dissolves over a prolonged period, while Effexor is an immediate-release medication.
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