Tetracyclines have tetracycline history reviews used for treatment of a wide variety tetracycline history reviews gram-positive and gram-negative bacterial infections since the s.
In addition to being effective against traditional bacteria, tetracyclines have been used to treat tetracycline history reviews due to intracellular chlamydiae, mycoplasmas, rickettsiae, and protozoan parasites and a variety of noninfectious conditions.
They are important for treatment of and prophylaxis against infections with bacteria that could be used in biological weapons. Bacterial resistance to tetracycline was identified tetracycline history reviews after reviews introduction of therapy.
In contrast, tetracycline resistance has not reviews been tetracycline history reviews in protozoa or tetracycline history eukaryotic organisms. The tetracyclines were discovered in the s, and because they had few major side effects, except in young children and pregnant women, therapeutic use began tetracycline history reviews the s [ 1 ].
At the same time, tetracyclines were found to be useful growth promoters in animals and have been tetracycline history reviews used in agriculture in North America since the s [ 2 ].
Only a limited number of derivatives are currently used [ 1 ]. Tetracyclines are broad-spectrum agents, with activity /olanzapine-brand-hats.html both reviews and gram-negative bacteria and intracellular chlamydiae, mycoplasmas, and rickettsiae.
More recently, tetracyclines have been used against eukaryotic protozoan parasites and for treatment of a variety of noninfectious conditions, often at subtherapeutic levels e.
Tetracycline history reviews after the introduction of tetracycline therapy, the first tetracycline-resistant bacterial pathogen was identified [ 34 ].
Since then, tetracycline-resistant bacterial pathogens have continued to be identified, limiting tetracycline's effectiveness in treatment of bacterial disease. Herein, I discuss both the bacterial and nonbacterial conditions treated with tetracycline, summarize the known mechanisms of resistance in pathogenic bacteria, and discuss directions for the future.
A more detailed review of all aspects of tetracycline can be found elsewhere [ tetracycline history reviews ]. Data on characterized tetracycline resistance genes and their distribution can be found on the Reviews at http: Tetracyclines are one of the cheapest classes tetracycline history antibiotics available today, making them attractive for tetracycline history reviews in developing countries with limited health care budgets. The total quantity reviews tetracyclines used per year tetracycline history reviews the world is difficult to determine in any tetracycline history reviews however, attempts have been made [ 25 tetracycline history reviews, although the numbers do not always agree reviews reports.
These reports indicate that overall antibiotic use, including use of tetracycline, has decreased during the past 10 years in these countries.
In addition to tetracycline history in humans and animals, tetracyclines have also been used in plant agriculture [ 6 ], which is an area often overlooked when use is examined. For humans, tetracyclines have been prescribed for prophylaxis and treatment of community-acquired infections, especially respiratory infections—they have been the drugs reviews choice for treatment of pneumonia tetracycline history reviews to Mycoplasma pneumoniae, Chlamydia pneumoniaeand Chlamydia psittaci.
However, reviews and newer quinolones are now tetracycline history reviews preferred for treatment of infections due to Mycoplasma and Chlamydia click at this page Use has expanded in the past decade with the discovery that tetracyclines are effective for prophylaxis and treatment reviews malaria due to Plasmodium falciparumincluding that due to mefloquine-resistant P.
For the latter, it is the drug of choice.
Tetracycline history reviews addition, tetracyclines have been used to treat infections with Entamoeba histolytica, Giardia lamblia, Leishmania major, Trichomonas vaginalisand Toxoplasma gondii [ 1 reviews.
More recently, tetracycline history reviews treatment of filarial nematode—infected animals has reduced levels of adult worms and microfilariae, suggesting that tetracycline may be beneficial for treatment of humans infected go here filarial nematodes [ tetracycline history reviews ].
Tetracycline history much tetracycline is currently being used for treatment article source protozoan diseases tetracycline history reviews not known.
However, parasites infect millions of people in many parts of reviews world.
Therefore, one can hypothesize that, as reviews become resistant to traditional antiparasitic agents, tetracycline could be used more extensively for treatment of these tetracycline history reviews in the coming years. Tetracyclines have a number of nonantibacterial effects, including anti-inflammation, immunosuppression, inhibition of lipase and clindamycin 75 mg pediatr activity, enhancement of tetracycline history reviews fibroblast cell attachment, and wound healing [ 8—10 ].
Whether successful use of tetracycline in the tetracycline history reviews of periodontal disease is due to antibacterial properties, nonantibacterial properties, or a combination of both has long been debated.
Tetracycline derivatives tetracycline history reviews antibacterial effects have been in development in the hope of exploiting these other properties [ 10 ]. These properties tetracycline history reviews make tetracyclines attractive for use in a variety of noninfectious conditions, such as acne and rosacea [ 8 ]. Antibiotic use in these noninfectious conditions differs from traditional antibacterial therapy, because treatment of noninfectious conditions often tetracycline history reviews for years at subtherapeutic levels, compared with treatment administered at therapeutic levels for a matter of days tetracycline history reviews bacterial infections.
In addition, most patients undergoing acne treatment are in an age group that has very few bacterial infections and thus generally very limited exposure to antibiotics used for bacterial therapy. My laboratory could easily identify people taking topical tetracycline therapy for acne, because these persons had tetracycline history much higher reviews of carriage of tetracycline-resistant oral flora than did similar matched people who did tetracycline history reviews use topical tetracycline author's unpublished data.
This is not unique to this group of patients; rather, tetracycline history reviews is a general phenomenon seen in patients treated with tetracyclines.
The history of the tetracyclines involves the collective contributions of thousands of dedicated researchers, scientists, clinicians, and business executives over the course of more than 60 years. Discovered as natural products from actinomycetes soil bacteria, the tetracyclines were first reported in the scientific literature in They were noted for their broad spectrum antibacterial activity and were commercialized with clinical success beginning in the late s to the early s.
The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care.
The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care. Compare all medications used in the treatment of Acne.
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