Quetiapine fumarate onset of action
Available forms Available by prescription only Tablets: Initially, 25 mg P.
Quetiapine - Wikipedia
quetiapine fumarate onset of action Further dosage adjustments, if indicated, should generally occur at intervals of at least 2 days. Dosages can be increased or decreased by 25 to 50 mg b. Antipsychotic efficacy usually occurs at to mg daily. For elderly or debilitated patients or those who have hepatic impairment or a predisposition to hypotensive reactions, consider lower doses, slower dosage adjustment, and careful monitoring during initial dosing period.
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Quetiapine in schizophrenia: onset of action within the first week of treatment.
Exact mechanism of action is unknown. Quetiapine is a quetiapine fumarate derivative that is thought to exert antipsychotic activity through antagonism of dopamine type 2 D 2 and serotonin type 2 5-HT 2 receptors. Antagonism at serotonin 5-HT 1AD 1H read article fumarate onset of action alpha quetiapine fumarate onset of action - and alpha 2 -adrenergic quetiapine action onset of action may explain other effects.
Rapidly absorbed after onset administration. Steady state levels are link within 2 days.
Extensively metabolized by the liver via sulfoxidation and oxidation.
Quetiapine
Cytochrome P 3A4 is the major isoenzyme involved. Mean terminal half-life is about 6 hours. Quetiapine fumarate onset of action and precautions Contraindicated in patients hypersensitive quetiapine fumarate onset of action drug or its components. Use cautiously in patients with CV or cerebrovascular disease, conditions that predispose to hypotension, conditions that could contribute to increased core body temperature, conditions that could lower the seizure threshold, or a history of seizures.
Quetiapine in schizophrenia: onset of action within the first week of treatment.
Also use cautiously in patients at risk for aspiration pneumonia from quetiapine fumarate onset of action dysmotility and aspiration. May potentiate hypotensive effects.
Barbiturates, carbamazepine, glucocorticoids, rifampin: Increases metabolism of quetiapine. Decreases oral clearance of quetiapine.
Quetiapine Fumarate Pharmacology
No dosage adjustment needed. May antagonize effects of these drugs. Erythromycin, fluconazole, itraconazole, ketoconazole: Increases oral clearance of quetiapine.
Quetiapine dosage may need adjustment. May potentiate cognitive and motor effects.
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Mechanism of action not fully understood: Blocks dopamine and serotonin receptors in the brain; also acts as a receptor antagonist at histamine and adrenergic receptor sites which may contribute to the adverse effects of orthostatic hypotension and somnolence.
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Quetiapine , marketed as Seroquel among other names, is an atypical antipsychotic used for the treatment of schizophrenia , bipolar disorder , and major depressive disorder. Common side effects include sleepiness, constipation , weight gain, and dry mouth. Quetiapine was developed in and approved for medical use in the United States in
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