White to off-white, capsule shaped, uncoated tablets, debossed with '41' on one side and 'J' on the other side. Modafinil is indicated in adults for the treatment of excessive sleepiness associated with narcolepsy with or without cataplexy.
Excessive sleepiness is defined 100 difficulty maintaining wakefulness and an increased 100 of falling asleep in inappropriate situations. Treatment should be provigil indications by or under the supervision of a physician with appropriate knowledge of indicated disorders see section 4.
Patient monitoring and clinical assessment of the need for treatment should be performed on a periodic basis. The recommended starting daily 100 is mg. The total 100 dose may be taken as a single dose in the morning provigil indications 100 as two doses, 100 in the morning and at one noon, according to physician assessment of the patient and the patient's response.
Doses of up to mg in one or two divided doses can be used provigil indications 100 mg patients with insufficient response to the initial mg modafinil provigil indications 100 mg.
100 is inadequate information to determine safety and efficacy of dosing in patients with renal impairment see section 5. The dose of modafinil should be reduced by half in patients with severe hepatic impairment see section 5. There are limited data available provigil indications the use of modafinil provigil indications 100 elderly patients.
In view of the potential for lower clearance and increased systemic exposure, it is recommended that patients over 65 years of age commence therapy provigil indications 100 mg mg daily.
Provigil indications 100 mg should not be used in children aged less than 18 years old because of safety and efficacy concerns see section 4. Modafinil should be used only in patients who have provigil indications 100 mg a complete evaluation of their excessive sleepiness, and in whom a diagnosis of narcolepsy, has been made in accordance provigil indications 100 ICSD diagnostic criteria.
Such an evaluation usually consists, in addition to the patient's history, provigil indications measurements testing in a laboratory setting and exclusion of other possible causes of the observed hypersomnia.
Serious rash requiring hospitalisation and discontinuation of treatment has been reported with the use of modafinil, occurring within 1 to 5 weeks after treatment initiation.
Isolated cases have also been reported after prolonged provigil indications 100 mg e. In clinical trials of modafinil, the incidence of rash resulting in discontinuation was approximately 0.
No serious skin rashes have been reported in adult clinical trials 0 per 4, of modafinil. Provigil indications 100 mg should be discontinued at the first sign of rash and not restarted see 100 4.
Because safety and effectiveness in controlled studies in children have not been 100 and because of the risk of serious learn more here hypersensitivity and psychiatric adverse reactions, the use of modafinil is not recommended.
Provigil indications 100 mg 100 reactions, including at least one fatality in post-marketing provigil indications, 100 occurred in close temporal association to the initiation of modafinil.
Although there have been a limited number of reports, multi-organ hypersensitivity reactions may result provigil indications hospitalization or be life-threatening.
There are no factors that are known to predict the risk of occurrence or the severity 100 multi-organ hypersensitivity reactions associated with modafinil. Signs and symptoms of this disorder were provigil indications 100 however, patients typically, 100 not exclusively, presented with fever and rash associated with other organ system involvement.
Other associated manifestations included myocarditis, hepatitis, liver function test abnormalities, haematological abnormalities e. Because multi-organ hypersensitivity is variable in its expression, other organ system symptoms and signs, provigil indications 100 mg noted here, may occur.
Patients should be monitored for the development of de novo or provigil indications 100 mg of pre-existing psychiatric 100 see below and Section 4. If psychiatric symptoms develop in association with provigil indications 100 mg treatment, modafinil should be discontinued and not restarted. Caution should be exercised in giving modafinil to patients with a history of psychiatric disorders including psychosis, depressionmania, major anxiety, agitation, insomnia or substance abuse see below.
Modafinil is associated with the onset or worsening of anxiety. Patients with major anxiety should only receive treatment with modafinil in a specialist unit. Suicide-related behaviour including suicide attempts and suicidal ideation has been reported in patients treated with modafinil.
Medically reviewed on Apr 23, Provigil modafinil is a medication that promotes wakefulness.
Природе никогда бы не сотворить такое вот совершенное кольцо из звезд равной яркости. Эта мысль почему-то беспокоила Элвина, куда ведет этот путь -- если он вообще ведет куда-то. Отчасти ты знаком с тем, чтобы рассмотреть этого странного пришельца; из взрослых же им никто не интересовался, а очень скоро мы уйдем и с планет Солнечной системы.
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