Lipitor for congestive heart failure

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Recent large clinical trials have yielded heart failure href="/micardis-80-mg-tablet-100mg.html">100mg tablet micardis mg 80 results of rosuvastatin in the chronic heart failure CHF population. The question that remains is whether these results of rosuvastatin studies could be extended to other statins. Therefore, we performed a meta-analysis based /arcoxia-vademecum-band.html all currently available randomized controlled trials RCTs lipitor for congestive evaluate the clinical efficacy of atorvastatin in CHF patients.

The published literature was scanned by formal searches of electronic databases up to Lipitor for RCTs were eligible for inclusion if congestive heart failure compared atorvastatin versus placebo treatment in patients with CHF and reported the clinical outcomes.

Pre-specified criteria were met by 7 trials involving patients. The primary endpoint, all-cause mortality, was significantly reduced lipitor for congestive heart failure atorvastatin therapy heart failure with placebo in CHF patients odds this web page [OR] 0. There lipitor for also a significant decrease in hospitalization for worsening CHF with atorvastatin lipitor for congestive compared with placebo OR 0.

This meta-analysis suggests the effectiveness of atorvastatin treatment in reducing lipitor for congestive heart failure risks of all-cause mortality and worsening CHF hospitalization in patients with CHF.

Further large, well-conducted randomized trials are needed to confirm the benefits of atorvastatin or other statins for CHF relative to congestive heart failure or rosuvastatin.

The 3-hydroxymethylglutaryl coenzyme A reductase lipitor for congestive heart failure statins reduce cardiovascular morbidity and mortality in patients with coronary artery disease CAD secondary preventionand in individuals at congestive heart risk of developing CAD primary prevention [ generic for imuran2 ].

However, the potential benefits of different statins in patients with chronic heart failure CHF remain controversial. Two recent large clinical trials lipitor for congestive heart failure specifically tested the effect of rosuvastatin in the CHF population, but both yielded disappointing results [ 34 ].

Whether these lipitor for congestive heart failure of rosuvastatin studies could be extended to the statin class or other statins is unclear. With regards to atorvastatin, the results of several small randomized controlled trials RCTs comparing it with placebo in patients with CHF have been reported [ 5 lipitor for congestive heart failure 19 ], but sample-size limitations in these studies prevented any reliable conclusion. Meta-analysis has the potential to increase the power and improve the precision of treatment effects [ 20 ].

Therefore, we performed a meta-analysis based on all currently available RCTs to evaluate the clinical efficacy of atorvastatin in patients with CHF. The search was restricted to articles indexed as a clinical trial involving human subjects.

LIPITOR: THE POISON THAT CAUSES CONGESTIVE HEART FAILURE

The last failure was performed in January To be selected for this meta-analysis, studies /benicar-vs-cozaar-interactions.html atorvastatin versus placebo treatment in patients with CHF congestive heart to be randomized and have their results reported or made available by the trial investigators. All studies meeting the requirements, regardless of the language or form of publication, were considered to learn more here eligible for this meta-analysis.

Failure primary end point was all-cause mortality. Other clinical outcomes of interest included cardiovascular lipitor for, sudden cardiac lipitor for congestive and worsening hospitalization for CHF.

heart failure

Two investigators independently performed data abstraction. In addition to pertinent data on the outcomes of interest, we gathered information on trial names, first author, year of publication, and number failure patients enrolled.

Disagreements were resolved by consensus. Failure were managed according to the intention-to-treat principle. Congestive heart failure pooled OR was calculated with the Mantel-Haenszel method congestive heart failure fixed effects and the DerSimonian and Laird method for random effects [ 2122 ].

Lipitor for assessed publication bias with respect to the primary outcomes of interest using a funnel plot as well as the adjusted congestive heart correlation test according to the method of Begg and Mazumdar [ 24 ]. A sensitivity analysis was performed by assessing the contribution of individual studies to the summary effect estimate with respect to link lipitor for congestive heart failure outcomes.

This was failure by excluding each trial one lipitor for a time and computing meta-analysis estimates for the remaining studies.

Statistical analyses were performed with Stata software lipitor for congestive heart failure 9. Of the potentially relevant articles initially screened, heart failure total of 15 trials that randomly compared atorvastatin therapy with placebo in patients with CHF lipitor for congestive heart failure initially identified [ 5 - 19 ].

Eight studies [ failure - 12 ] were then excluded due to the prospective crossover design or the lack of data check this out clinical outcomes.

Thus, a total of 7 RCTs were congestive heart failure included in this meta-analysis, involving patients in the atorvastatin group and controls [ 13 - 19 ]. The primary endpoint, all-cause mortality, was reported in all 7 trials.

Omission of individual trials from the read more did not have any relevant lipitor for congestive heart failure on the overall results. Odds ratios of all-cause mortality associated with atorvastatin versus placebo from individual studies and overall population. The size of the data markers squares is approximately proportional to the statistical weight of each trial.

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