Digoxin is a cardiac glycoside that increases the force of elderly nice contraction and reduces conductivity within the atrioventricular AV node. Digoxin dose by intravenous infusion.
Manufacturer advises reduce dose by half with concurrent use of elderly nice, dronedarone and quinine. Dose may need to be reduced if digoxin or another cardiac glycoside has been given in the preceding 2 weeks.
Constrictive pericarditis unless to control atrial fibrillation or improve systolic dysfunction—but use with caution ; hypertrophic cardiomyopathy unless concomitant atrial fibrillation and heart failure—but use with caution ; intermittent complete heart block ; blood test zip lamisil ; second degree AV /singulair-medicine-dosage-interactions.html ; supraventricular arrhythmias associated with accessory conducting pathways e.
Wolff-Parkinson-White syndrome although can be used in infancy digoxin dose ventricular digoxin dose or fibrillation. Hypercalcaemia risk of digitalis toxicity ; hypokalaemia risk of digitalis toxicity ; hypomagnesaemia risk of nice toxicity ; hypoxia risk of digitalis toxicity ; recent myocardial infarction ; severe respiratory disease ; sick sinus syndrome ; thyroid disease.
Arrhythmias ; cardiac conduction disorder ; cerebral impairment ; diarrhoea ; dizziness ; eosinophilia ; nausea nice skin reactions ; vision disorders ; vomiting. Appetite decreased ; asthenia ; confusion ; gastrointestinal elderly elderly ; gynaecomastia ; headache ; malaise ; psychosis ; thrombocytopenia.
If toxicity occurs, digoxin should be withdrawn; serious manifestations require urgent specialist management. To be given over at least 2 hours.
Forms available from special-order manufacturers include: TabletSolution for injectionSolution for infusionOral solution. Show all parts of this monograph Drug action Indications and dose Unlicensed use Contra-indications Cautions Interactions Side-effects Pregnancy Breast feeding Renal impairment Monitoring requirements Directions for nice Patient and carer digoxin dose in elderly nice Medicinal forms Drug action Digoxin is a cardiac glycoside that increases the force of myocardial contraction and reduces conductivity within the atrioventricular AV node.
Rapid digitalisation, for atrial fibrillation or flutter By mouth For Adult 0. 7 male nice year benefits for old powder mouth For Digoxin dose Initially by intravenous infusion For Adult Loading dose 0. elderly
Digoxin doses in the BNF may differ /what-does-ampicillin-do-for-the-body.html those in product literature.
Common or very common Arrhythmias ; cardiac conduction disorder digoxin dose in elderly nice cerebral impairment ; diarrhoea ; dizziness ; eosinophilia ; nausea ; skin reactions ; vision disorders ; vomiting. Rare digoxin dose very rare Appetite decreased elderly nice asthenia digoxin dose in elderly nice confusion ; gastrointestinal disorders elderly nice gynaecomastia ; headache ; malaise ; psychosis ; digoxin dose.
Overdose If toxicity occurs, digoxin should be withdrawn; serious elderly nice require urgent specialist management. Dose adjustment May need dosage adjustment.
Amount too small to be harmful. Dose adjustments Reduce dose. Monitor plasma-digoxin concentration in renal impairment. Therapeutic drug monitoring For plasma-digoxin concentration assay, blood should be taken at least 6 hours after a dose. Monitor serum electrolytes digoxin dose in elderly nice renal function. Toxicity increased by electrolyte disturbances. /what-color-is-lithium-your-body.html
With intravenous use Avoid rapid intravenous administration risk of hypertension and reduced coronary flow. For oral administration, oral solution must not be diluted. Patient counselling is advised for digoxin elixir use pipette.
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Old people, especially the very old, require special care and consideration from prescribers. National Service Framework for Older People. Department of Health, March , describes how to maximise the benefits of medicines and how to avoid excessive, inappropriate, or inadequate consumption of medicines by older people.
The intravenous route should be reserved for use in patients requiring urgent digitalisation for supraventricular arrhythmias atrial fibrillation or flutter , or if patients are NBM or vomiting. Oral is the prefered route.
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