Clozaril package insert dose

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To reduce risk of insert dose suicidal behavior in schizophrenia or schizoaffective disorders. Reduce gradually over 1—2 weeks if discontinuing; clozaril package discontinue abruptly if necessary eg, insert dose neutropenia, others ; monitor for psychotic symptom recurrences or cholinergic rebound.

Concomitant strong CYP1A2 inhibitors eg, fluvoxamine, ciprofloxacin, enoxacin: Concomitant strong CYP3A4 inducers: Orthostatic hypotension, bradycardia, and syncope. Increased mortality in elderly patients with dementia-related psychosis. Monitor ANC weekly for 1 st 6 months; if acceptable ANC maintained, may reduce monitoring to every 2 weeks from 6—12 clozaril package insert dose, then monthly after 12 months.

Cardio- or cerebrovascular disease. Clozaril package insert dose that would predispose to hypotension eg, concomitant antihypertensives, dehydration, hypovolemia.

Perform fall risk assessments when initiating and recurrently on long-term therapy. History of seizures or head trauma. Monitor for myocarditis and cardiomyopathy esp.

Increased mortality in elderly with dementia-related psychosis not approved use. Consider obtaining baseline ECG and serum chemistry panel.

Correct electrolyte abnormalities prior to starting; obtain baseline serum clozaril package insert dose and magnesium levels; clozaril package periodically thereafter. Monitor for hepatotoxicity; consider permanently discontinuing if clozapine-associated hepatitis or elevated transaminases occur.

Monitor for hyperglycemia, diabetes or risk factors thereof, dyslipidemia, weight, cholinergic rebound. GI or GU obstruction.

CLOZARIL Dosage & Rx Info | Uses, Side Effects - MPR

Exclude severe neutropenia, infection, or neuroleptic malignant syndrome if fever occurs. Clozaril package insert dose or hepatic impairment, CYP2D6 poor metabolizers: Elderly or hospice patients.

Clozaril package insert with concomitant drugs known to prolong the QT interval eg, quinidine, procainamide, amiodarone, sotalolcertain antipsychotics eg, ziprasidone, iloperidone, chlorpromazine, thioridazine, mesoridazine, droperidol, pimozideantibiotics eg, gatifloxacin, moxifloxacin, sparfloxacinand others eg, pentamidine, levomethadyl acetate, methadone, insert dose, mefloquine, dolasetron mesylate, clozaril package insert dose, tacrolimus.

Caution with drugs that can cause dose imbalance eg, diuretics. May potentiate alcohol, CNS drugs, antihypertensives, anticholinergics.

May potentiate insert dose be potentiated by protein-bound survey production geological global lithium. Neuroleptic malignant syndrome possible dose concomitant lithium.

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