The patient experienced a citalopram therapeutic dose qt interval prolongation tachycardia leading to cardiac arrest and was found to have a prolonged QT interval.
Prolongation patient was in end stage renal failure. Although citalopram is eliminated more slowly in patients with mild to moderate renal impairment a dose adjustment is not necessary.
However, no information is available on treatment of patients with severely reduced renal function and prescribers are advised to use caution 1. Healthcare professionals are reminded that citalopram is associated with a dose dependent increase in the risk of QT prolongation 2. The maximum dose of citalopram is 40 mg a day due to the increased risk of QT citalopram therapeutic dose with click the following article additional benefit 1.
In elderly patients, patients with reduced hepatic function, patients who are CYP2C19 interval metabolisers, and prolongation taking CYPC19 inhibitors eg, citalopram therapeutic dose qt interval prolongation and omeprazolethe maximum dose should not exceed 20 mg a day because these citalopram therapeutic dose qt interval prolongation lead to increased blood levels of citalopram 1.
citalopram therapeutic dose qt interval prolongation QT prolongation is a measure of /brahmi-shak-york-pa.html ventricular repolarisation, which can cause Torsades de Pointes, citalopram therapeutic dose qt interval prolongation tachycardia, and sudden death.
A corrected QT interval QTc of greater than ms or an increase in the QTc of greater than 60 ms is considered interval confer a high risk of Torsades de Pointes 3. Citalopram should be discontinued and specialist advice sought in patients who are found to have persistent QTc greater than ms or an increase of citalopram therapeutic dose learn more here 60 ms unless there are prolongation reasons to continue.
QT prolongation risk factors include female gender, increasing age, genetic predisposition, structural heart disease, hypokalaemia, hypomagnesaemia, and interactions with other medicines 3.
Prescribers should advise patients citalopram therapeutic dose qt interval prolongation contact a healthcare professional immediately if they experience signs and symptoms of an abnormal heart rate or rhythm while taking citalopram. Key Messages Citalopram therapeutic dose qt interval prolongation maximum dose of citalopram for elderly patients, patients with hepatic impairment, and patients who are CYP2C19 poor metabolisers, or who are taking CYP2C19 inhibitors is 20 mg daily due to prolongation risk of QT prolongation.
The maximum dose for other patients is 40 mg daily. Patients should be screened for risk factors for QT prolongation before starting treatment with citalopram. Patients should be advised to contact a healthcare professional immediately if they experience signs and symptoms of an abnormal heart rate or citalopram therapeutic dose qt interval prolongation while taking citalopram.
Initially, quizzes are posted out with journals and GPs are invited to submit their answers for CME credits. Register or Log in to take part in quizzes. Don't have an account?
UK uses cookies to make the site simpler. Find out more about cookies. New maximum daily dose restrictions including in elderly patients , contraindications, and warnings.
Information on this subject has been updated. Read the most recent information.
2018 ©